Recent studies have shown Hydrogen sulfide (H2S) to have a significant signaling role in biomedicine and biology. In particular, H2S, which is produced in the cardiovascular system of mammals, was found to lead to dilation of blood vessels and the lowering of blood pressure.
One of the problems in studying this relatively newly discovered gaseous signaling molecule is accurately measuring H2S concentration in biological media. Polarographic and chromatographic methods, which were previously used, not only suffer from significant interferences but also require labor-intensive sample prep procedures which can lead to H2S loss from the sample.
A recent study by Yang* et al just published in SCIENCE uses a unique method to measure H2S concentration. The paper entitled "H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine -Lyase" uses a micro H2S electrode developed by LAZAR RESEARCH LABORATORIES, INC., Los Angeles, CA.
This unique electrode is the smallest ion electrode of its kind and can measure volumes down to 10 microliters in samples such as 96 well plates. H2S can be measured down to less than 0.1 Micro Molar concentration (less than 100 nano Molar). Sample prep is simple and done directly in the 96 well plate or other micro sample container thereby minimizing H2S loss and increasing accuracy. Unlike other methods, this micro electrode measurement method has no known interferences.Unique features of the Micro H2S
- Measure micro samples- Measure samples as small as 10 microliters in samples such as 96 well plates
- Low detection limit- Measure H2S concentrations as low as 0.1 micro Molar (100 nano Molar)
- Simple sample prep- one step sample prep done directly in the micro sample container
- Cost effective- significant savings over other techniques such as chromatography and polarography
- Use directly with your PC or laptop- Connects directly to your USB port for logging, graphing, and data recording directly on your PC
- No known interferences unlike chromatography and polarography